Needs VoiceOver!
At the moment, the Amazon Kindle For Mac app is woefully inaccessible to disabled Mac users. There is no automated way to launch & control voiceover reading. The only way is to manually highlight the text and have the mac read using its narration software.
Note that automated narration IS AVAILABLE FOR THE PC. [eye roll]
Amazon, please update your Mac software to make it more accessible to everyone.
Reitveld about Kindle Classic